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FHIR Interoperability Resource Center

The latest guides, tools and insights on healthcare interoperability, FHIR standards, and secure, compliant data exchange for innovative healthcare organizations.

CommercialMedicaid
  • The Payer-to-Payer Gap: From CMS-0057 Compliance to Real Data Exchange
  • A playbook on why a compliant Payer-to-Payer API isn't the same as real data exchange, with a case study on closing that gap.
Customer Story
  • Regional Blues Plan Modernizes Interoperability Solution
CommercialMedicaid
  • CMS-0057 Compliance: Why FHIR APIs Are Not Enough
  • An ebook on how network strategy, provider relationships, and member workflows power healthcare data exchange.
MedicaidMedicare
  • CMS-0057 Audit Readiness Quick-Start Guide
  • A quick-start guide to building defensible API audit logs ahead of CMS-0057 enforcement.

Videos

Understanding FHIR
CommercialMedicaid
  • Understanding FHIR
  • A plain-language introduction to what FHIR is and why it matters for health data exchange.
How FHIR Works
CommercialMedicaid
  • How FHIR Works
  • A closer look at how FHIR standards actually move and structure health data.

Briefs, eBooks, Reports & more

Stay up to date with the latest from 1upHealth​

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The 2026-2027 Interoperability Readiness Guide
BCBSA Interoperability HubCMS-0057
  • Blues Plan’s Guide to 2026-2027 Interoperability Readiness
  • An ebook for Blues plans on the four converging CMS-0057-F and BCBSA Interoperability Hub deadlines, plus a tiered readiness self-assessment.
CommercialMedicaid
  • 1up Formulary
  • Deliver transparent drug coverage details to members and providers.
CommercialMedicaid
  • What Sets 1upHealth Apart from Other Vendors
  • A side-by-side comparison of 1upHealth against other interoperability vendors, across cost, architecture, integration, and long-term ROI.
cloud-based platform
CommercialMedicaid
  • 1up Platform
  • Learn how to simplify how you acquire, manage, and use healthcare data with a scalable, FHIR-first platform.
CMS resolutions icon
MedicaidMedicare
  • 1up CMS-0057-F Solutions
  • An overview of 1up's CMS-0057-F solution suite in one document.
Payer to Payer Data Exchange
CommercialMedicaid
  • 1up Payer-to-Payer Data Exchange
  • Unlock historical member data to improve onboarding and close care gaps.
illustration of the electronic prior authorization process
CommercialMedicaid
  • 1up Electronic Prior Authorization
  • Automate prior authorization to deliver faster decisions and better experiences.
Provider Access
CommercialMedicaid
  • 1up Provider Access
  • Enable providers with timely patient data for better care decisions.
CommercialMedicaid
  • 1up Provider Directory
  • Publish accurate provider directories that make in-network care easy to find.
1upHealth 2025 Payer’s Guide to Interoperability ebook
MedicaidMedicare
  • Payer’s Guide to Interoperability: How to plan, implement, and maximize value for CMS-0057
  • An ebook covering what CMS-0057 requires, checklists for getting your health plan ready, and the technical foundation you'll need.
1upHealth: FHIR & the Art of the Possible Web Series Episode 1
CommercialMedicaid
  • FHIR & the Art of the Possible
  • A web series exploring what's possible in healthcare once FHIR-based interoperability is in place.
1up Patient Access
CommercialMedicaid
  • 1up Patient Access
  • Learn how to give members easy, secure access to their health information.
1upHealth Spotlight
CommercialMedicaid
  • Glossary
  • Plain-language definitions of the FHIR, interoperability, and CMS terms you'll run into most often.
Questions and Answers
MedicaidMedicare
  • CMS Final Rule FAQs
  • Quick answers to the most common questions about what CMS-0057-F and CMS-9115-F actually require.
Pharmacist using a tablet
MedicaidMedicare
  • Provider Directory API
  • A breakdown of the CMS Provider Directory requirement and what it takes to keep listings accurate and compliant.

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