Are you ready for CMS-0057 and future interoperability requirements?
1upHealth is the interoperability vendor of choice for 80+ Medicare, Medicaid, and commercial payers. Learn why.
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What’s Your Interoperability Strategy?
According to WEDI’s 2025 “CMS Interoperability and Prior Authorization Final Rule Survey”, the majority of payer respondents had not yet started preparing for compliance with CMS-0057 API requirements. With the deadline looming, now is the time to act.
Your approach to Patient Access and Interoperability (CMS-9115) compliance will not suffice for Prior Authorization and Interoperability (CMS-0057), which is much more complex and far-reaching.
Now is the perfect time to rethink your interoperability strategy and the technology foundation required.
Health Data, On Demand
1upHealth is the market leader helping Medicare, Medicaid, and commercial payers easily acquire, manage, share, and analyze health data in real time and at scale, supporting not only their regulatory requirements but also helping them drive ROI from their interoperability investments.






Make the Move to 1upHealth

Go from Basic Data Exchange to Computable Interoperability
Go beyond the batch and highly manual movement of data and turn health data into a continuous stream of actionable information that can be combined, analyzed, and used across systems in near real time.

Go from Dated Architecture to the Leading Health Data Management Platform (HDMP)
The 1up Platform is the market's most advanced, FHIR-native HDMP. Purpose-built for healthcare on a next-generation data lakehouse architecture, our platform leverages industry-standard, open-source technologies for real-time exchange and analytics.

Go from Compliance to Interoperability as a Strategic Advantage
Go beyond satisfying regulatory requirements to make interoperability a strategic advantage for improvements in areas like Star Ratings, quality management, risk adjustment, care management, and member and provider engagement.
What Customers are Saying




Why Payers Have Made the Move to 1upHealth

An industry-leading, standards-first, FHIR-native platform

A dedication to compliance, with the most CMS FHIR APIs in the industry

Deep industry experience, with a customer base of over 80 payers

Dedicated account teams driving meaningful outcomes

Fast implementations and 24/7/365 US-based support

Competitive pricing to earn your business

Flexibility to meet you where you are in your interop journey

A robust network of 7,500+ provider and 130+ payer endpoints
1up Payer Solutions

1up Platform
Unlock the power of computable interoperability and transform how you acquire, manage, share, and analyze health data.

1up Comply
Meet regulations without the hassle of building in-house or working with inexperienced vendors with our integrated compliance solution.
Payer Resources
Meet the Team
Our team offers deep industry experience and looks forward to meeting and supporting you, no matter where you are in your interoperability journey.



